Selected publications:
de la Rocha-Muñoz, A., Núñez, E., Vishwanath, A. A., Gómez-López, S., Dhanasobhon, D., Rebola, N., López‐Corcuera, B., de Juan-Sanz J* & Aragón, C. (2021). The presynaptic glycine transporter GlyT2 is regulated by the Hedgehog pathway in vitro and in vivo. Communications Biology, 4(1), 1-10. * Corresponding author.
Ashrafi, G.*, de Juan-Sanz, J*, Farrell, R.J. and Ryan T.A. (2020). Molecular tuning of the axonal mitochondrial Ca2+ uniporter ensures metabolic flexibility of neurotransmission. Neuron, 105(4), 678-687.. * Co-first authors.
de la Rocha-Muñoz A., Núñez, E., Arribas-González, E., López‐Corcuera, B., Aragón, C* and de Juan-Sanz J* (2019). E3 ubiquitin ligases LNX1 and LNX2 are major regulators of the presynaptic glycine transporter GlyT2. * Co-corresponding authors. Scientific Reports. 9, 14944
Koopmans F, van Nierop P, Andres-Alonso M, (…) Malenka R, Nicoll RA, Pulido C, de Juan-Sanz J, Sheng M, Südhof TC, (…) Thomas PD, Smit AB, Verhage M (2019). SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse. Neuron, 103(2):217-234
Wang, Y., Subramanian, M., Yurdagul, A., Barbosa-Lorenzi, V. C., Cai, B., de Juan-Sanz, J., … & Tabas, I. (2017). Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages. Cell, 171(2), 331-345.
de Juan-Sanz, J., Holt, G. T., Schreiter, E. R., de Juan, F., Kim, D. S., & Ryan, T. A. (2017). Axonal endoplasmic reticulum Ca 2+ content controls release probability in CNS nerve terminals. Neuron, 93(4), 867-881.
Other publications:
Chen, C.C., Chen, B.R., Wang, Y., Curman, P., Beilinson, H.A., Brecht, R.M., Liu, C.C., Farrell, R.J., de Juan-Sanz, J., Charbonnier, L.M. Kajimura, S… & Sleckman, B. P. (2021). 2021. Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activity is required for V (D) J recombination. J Exp Med, 218(8), p.e20201708.
Pascual-Caro, C., Orantos-Aguilera, Y., Sanchez-Lopez, I., de Juan-Sanz, J., Parys, J.B., Area-Gomez, E., Pozo-Guisado, E. and Martin-Romero, F.J. (2020). STIM1 Deficiency Leads to Specific Down-Regulation of ITPR3 in SH-SY5Y Cells. Int. J. Mol. Sci 21, 6598
Weatherly, L. M., Nelson, A. J., Shim, J., Riitano, A. M., Gerson, E. D., Hart, A. J., de Juan-Sanz, J., … & Gosse, J. A. (2018). Antimicrobial agent triclosan disrupts mitochondrial structure, revealed by super-resolution microscopy, and inhibits mast cell signaling via calcium modulation. Toxicol and app pharm,, 349, 39-54.
Chakrabarti, R., Ji, W. K., Stan, R. V., de Juan Sanz, J., Ryan, T. A., & Higgs, H. N. (2018). INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division. J Cell Biol,, 217(1), 251-268.
Arribas-González, E., de Juan-Sanz, J., Aragón, C., & López-Corcuera, B. (2015). Molecular Basis of the Dominant Negative Effect of a Glycine Transporter 2 Mutation Associated with Hyperekplexia. J Biol Chem, 290:2150-2165.
de Juan-Sanz, J., Núñez, E., Zafra, F., Berrocal, M., Corbacho, I., Ibáñez, I., … & Aragón, C. (2014). Presynaptic control of glycine transporter 2 (GlyT2) by physical and functional association with plasma membrane Ca2+-ATPase (PMCA) and Na+-Ca2+ exchanger (NCX). J Biol Chem. 289:34308-34324.
de Juan-Sanz, J., Nunez E, Villarejo-López L, Pérez-Hernández D, Rodriguez-Fraticelli AE, López- Corcuera B, Vazquez J, Aragón C (2013). Na/K ATPase is a new interacting partner for the neuronal glycine transporter GlyT2 that downregulates it expression in vitro and in vivo. J Neurosci 33:14269-81
de Juan-Sanz, J., Nunez E, López-Corcuera B, Aragón C. (2013). Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster. PLoS One 8(3): e58863. doi:10.1371/journal.pone.0058863
de Juan-Sanz, J., Nunez E, López-Corcuera B and Aragón C. (2013). Regulation of the glycinergic neurotransmission during inflammatory pain: A new pathway in the action of Prostaglandin E2 in the spinal cord. Real Acad. Nal. Farm. 79 (3), 434-449.
Giménez C, Pérez-Siles G, , Arribas-González E, Jiménez E, Núñez E, de Juan-Sanz, J.,, Fernández-Sánchez E, García-Tardón N, Ibáñez I, Romanelli V, Nevado J, James VM, Topf M, Chung SK, Thomas RH, Desviat LR, Aragón C, Zafra F, Rees MI, Lapunzina P, Harvey RJ, López-Corcuera B. (2012). A novel dominant hyperekplexia mutation Y705C alters trafficking and biochemical properties of the presynaptic glycine transporter GlyT2. J Biol Chem. 287:28986-9002. doi: 10.1074/jbc.M111.319244.
de Juan-Sanz, J.,, Zafra F, López-Corcuera B, Aragón C. (2011). Endocytosis of the Neuronal Glycine Transporter GLYT2. Role of Membrane Rafts and Protein Kinase C-dependent Ubiquitination. Traffic. 12:1850-67. doi: 10.1111/j.1600-0854.2011.01278.x.
